According to Comics Alliance, Oni Press announced that they are going to bring the rest of "Scott C" Campbell's Double Fine Action Comics to trade paperback.
Starting in 2013, they will be bringing the first volume, Double Fine Action Comics Vol. 1, back into print, and will be following that up with Double Fine Action Comics Vol. 2. The first volume contains the first 300 strips and has a foreword by Tim Schafer, while the second volume contains the next 200 strips and has a foreword by Erik Wolpaw. A third volume, which is said to collect the remainder of the run (although it's unknown whether that's the original run, or if it includes the new comics as well), will be coming afterward.
As a side note, Double Fine Action Comics has been restarted after a long hibernation, so be sure to check that out if you haven't already.
Also, while I'm on the subject of the Double Fine Comics, I'll take the time to mention that Tasha's Comic moved to the personal blog of Tasha Harris after she left Double Fine for Pixar last September (the original run of the comic is still available at the Double Fine website as well). The other on-going Double Fine comics are Nathan Stapley's My Comic About Me and Gabe Miller's Dirt Nap. All are worth reading. The latter, in particular, is very engrossing. I'm not ashamed to admit that I'm addicted to it.