A hacker named Ryan Souders, aka HonkeyKong, has released a patch for Maniac Mansion for the Nintendo Entertainment System that allows it to have real mouse support through the SNES Mouse via a Super Nintendo Entertainment System to Nintendo Entertainment System controller adapter.
The project's Romhacking page mentions this patch is for the North American NTSC release of Maniac Mansion.No word on whether the hamster cruelty-free European PAL version or the censorship-free prototype version is, or will be, supported, but I'll keep you posted (or most likely Jason will since I'm as common as the Nintendo PlayStation around here nowadays).