Gamasutra has posted an analysis of DeathSpank's chuckle-inducing characteristics, using the game's "integrated design for comedy" to explore the success and prevalence of humor in games in general.
How telling is it that Ron Gilbert and Tim Schafer, who arrived on the scene together over 20 years ago, remain the only two designers most gamers can think of when it comes to comedic games? It's a worn-out cliche, but it remains true: comedy is hard - hard work; hard to produce; and hard to perform.
Source: Gamasutra