Consequently, this update is more than just tweaked visuals and lighting. There are fundamentally new music cues, different camera angles, and altered timing for jokes. They recast the voice actor for Bosco, because it was a black character voiced by a white actor, a creative decision that didn't exactly sit right with the team when they decided to revisit it.
We can only assume Skunkape accidentally sent this interview to Vice instead of us, but either way… After we exclusively/allegedly broke the news of Sam & Max Save the World: Remastered, this is a good follow-up read. An excerpt:
Go read the whole thing.