Looking through all the recent Sam and Max news posts on the site, I came across an interesting comment on GameDreamZ.com - basically, Dan Connor says that he thinks "the game would do great on the Wii."
With a DVD release of the game defacto confirmed after all the Webisodes have been released, perhaps we'll get lucky and see it ported over to the Wii? The Wiimote is perfectly adapted to point-and-click games, and Sam and Max is certainly the unique kind of license Nintendo seem to thrive on.
Time will tell, of course.
Source: GameDreamZ.com