While it will come as no surprise to anybody, in a shaky-cam interview by joystiq, Dave Grossman reveals that Sam & Max season 2 planning is already underway, and that season 1 story arc will wrap up with episode 6 and not carry over to season 2. Of course merely being 'planned' doesn't necessarily mean the thing will go into production, but I'd say chances are pretty good.
The same stunt camera-crew also interview Steve Purcell here.
And if you want to know why everyone's so drunk, you can blame the blue cocktails.
Source: Joystiq
So comedy FPS's can be done.