Bad Brain Entertainment, the company who is financing and publishing Autumn Moon's A Vampyre Story, has just put up their website, indicating a 2nd Quarter '06 release for "Vampyre".
Autumn Moon is made up of ex-LucasArts talent, and is run by Bill Tiller. There are also strong indicators that Bad Brain is trying to aquire LucasArts unfinished Sam & Max 2 code.
Bad Brain also have a couple of internally produced adventure games in the works, the promising & hilarious sounding The Orgastic Four and an intriguing multi-player adventure, the X-Filesesque I-JET.
To learn more, check out their site; bad-brain.com
Source: Bad Brain Entertainment
And there's a whole lot LESS prominent talk about Sam & Max 2, which is also a plus.